Abstract #0846

Metabolic Changes in a Rat Glioma Model After Anti-Angiogenic Treatment Measured by MR Spectroscopic Imaging of Hyperpolarized [1-13C]Pyruvate

Jae Mo Park ¹ , Sonal Josan ¹ , Taichang Jang ² , Milton Merchant ² , Ralph Hurd ³ , Dirk Mayer ⁴ , Lawrence Recht ² , and Daniel Spielman ¹

¹ Radiology, Stanford University, Stanford, CA, United States, ² Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, ³ GE Healthcare, CA, United States, ⁴ Diagnostic Radiology and Nuclear Medicine, University of Maryland, MD, United States

We hypothesize that, in addition to changes in permeability, anti-VEGF drug also acutely and temporarily forces increased oxidative phosphorylation in glioma tissue due to nutrient depletion, increasing tumor vulnerability. Using an optimized 13C MRS imaging sequence, we were able to reproducibly image 13C-Bic in addition to 13C-Lac labeling using hyperpolarized [1-13C]Pyr in tumor-bearing rats, reflecting oxidative phosphorylation and glycolysis, respectively. After anti-VEGF treatment, Lac/Bic decreased significantly (at 3h post-treatment) and gradually increased back (24h and 48h post-treatment) in glioma while Lac/Bic did not have metabolic perturbation due to the drug. The increased Lac/Bic at 24h and 48h relatve to 3h suggests this might be a temporary phenomenon. We suggest that real time Bic measurements may provide both a useful biomarker for anti-angiogenic therapies and a potentially exploitable therapeutic strategy.

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