Molecular Signaling Pathway Intervention of Fibrotic Alterations of Myo-architecture of Rabbit External Anal Sphincter Muscle following Surgical Myotomy a DTI Fiber Tracking Study.

DTI and Fiber Tracking were used to characterize in a rabbit model, the architecture of external anal sphincter (EAS) muscle in (i) intact form, (ii) recovering untreated from surgical myotomy and, (iii) same as (ii) but treated with a pharmacological intervention of Wnt antagonist, SFRP-2. In (i) and (iii) tensors showed very homogenous well-ordered distribution while fiber tracking yielded long, continuous fibers, in contrast to the untreated (ii) which showed very heterogeneous tensor parameters and short fibers. Thus DTI and FT could demonstrate fibrosis in untreated muscle recovering from injury as well as its reversal by molecular signaling pathway intervention.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.