3D whole-heart quantitative first-pass perfusion imaging with a stack-of spirals trajectory
Yang Yang 1 , Xiao Chen 1 , Frederick H. Epstein 1,2 , Craig H. Meyer 1,2 , Christopher M. Kramer 2,3 , and Michael Salerno 2,3
Biomedical Engineering, University of
Virginia, Charlottesville, VA, United States,
University of Virginia, Charlottesville, VA, United
Medcine, University of Virginia,
Charlottesville, VA, United States
Volumetric quantitative myocardial first-pass perfusion
CMR imaging with adenosine stress could improve
diagnosis of coronary artery disease and quantification
of ischemic burden. Spiral pulse sequences have multiple
advantages for perfusion imaging, and preliminary
studies have suggested that a 3D stack-of-spirals pulse
sequence is feasible for first pass perfusion imaging.
To obtain a full 3D quantitative assessment of
myocardial perfusion, we have developed an accelerated
3D stack-of-spirals pulse sequence using motion
compensated parallel imaging, compressed sensing, and an
integrated single-shot arterial input function
acquisition and demonstrate its successful application
in healthy human subjects.
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