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Abstract #0878

3D whole-heart quantitative first-pass perfusion imaging with a stack-of spirals trajectory

Yang Yang 1 , Xiao Chen 1 , Frederick H. Epstein 1,2 , Craig H. Meyer 1,2 , Christopher M. Kramer 2,3 , and Michael Salerno 2,3

1 Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 2 Radiology, University of Virginia, Charlottesville, VA, United States, 3 Medcine, University of Virginia, Charlottesville, VA, United States

Volumetric quantitative myocardial first-pass perfusion CMR imaging with adenosine stress could improve diagnosis of coronary artery disease and quantification of ischemic burden. Spiral pulse sequences have multiple advantages for perfusion imaging, and preliminary studies have suggested that a 3D stack-of-spirals pulse sequence is feasible for first pass perfusion imaging. To obtain a full 3D quantitative assessment of myocardial perfusion, we have developed an accelerated 3D stack-of-spirals pulse sequence using motion compensated parallel imaging, compressed sensing, and an integrated single-shot arterial input function acquisition and demonstrate its successful application in healthy human subjects.

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