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Abstract #0877

Robust Cardiac BOLD MRI using an fMRI-like approach with Repeated Stress Paradigms

Aurelien F. Stalder 1 , Michaela Schmidt 1 , Andreas Greiser 1 , Peter Speier 1 , Jens Guehring 1 , Matthias G Friedrich 2,3 , and Edgar Mueller 1

1 Siemens AG Healthcare Sector, Erlangen, Germany, 2 Departments of Cardiology and Radiology, Montreal Heart Institute, Universit de Montral, Montreal, QC, Canada, 3 Departments of Cardiac Sciences and Radiology, University of Calgary, Calgary, AB, Canada

The diagnostic accuracy of cardiac BOLD MRI remains limited by its signal amplitude being in the order of magnitude of noise and signal variations due to hardware instabilities or other physiological effects, and cardiac and respiratory motion. In this work, we combined a fast BOLD-sensitive acquisition technique with elastic motion-correction and an fMRI-like (GLM) data analysis. The method was applied in 13 volunteers performing repeated breath-holds. Pixel and ROI based analysis derived statistically significant BOLD activations in the myocardium. Robust oxygenation-sensitive CMR as a non-invasive contrast-free technique may become an alternative to current diagnostic tools in patients with suspected CAD.

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