Abstract #0876
Diagnosis of diastolic dysfunction by shear wave amplitudes measured in cardiac MR elastography
Thomas Elgeti 1 , Fabian Knebel 2 , Ingo Steffen 1 , Bernd Hamm 1 , Jrgen Braun 3 , and Ingolf Sack 1
1
Department of Radiology, Charit
Universittsmedizin Berlin, Berlin, Germany,
2
Department
of Cardiology and Angiology, Charit Universittsmedizin
Berlin, Berlin, Germany,
3
Department
of Medical Informatics, Charit Universittsmedizin
Berlin, Berlin, Germany
Cardiac MR elastography (cMRE) can detect altered
mechanical tissue properties, which cause diastolic
dysfunction. In this study, time harmonic shear wave
amplitudes (SWA) were measured in 50 subjects including
30 patients with cardiac relaxation abnormalities by
cMRE for the quantification of the symptomatic and
asymptomatic ability of the myocardium to mechanically
relax. Compared to controls, patients displayed
significantly reduced SWA which was inversely correlated
to the severity of diastolic dysfunction. Best
cutoff-value to differentiate between volunteers and
patients was 0.43 yielding an AUROC value of 0.92 with
90% sensitivity and 89.7% specificity.
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