Assessment of diastolic dysfunction in hypertensive patients using full-cycle cine DENSE
Bhairav Bipin Mehta 1 , Sujith Kuruvilla 2 , Michael Salerno 1,2 , and Frederick H Epstein 1,3
Department of Biomedical Engineering,
University of Virginia, Charlottesville, Virginia,
of Medicine, Cardiology Division, University of
Virginia, Charlottesville, Virginia, United States,
of Radiology and Medical Imaging, University of
Virginia, Charlottesville, Virginia, United States
Diastolic dysfunction is independently associated with
increased cardiovascular mortality. Echocardiography is
commonly used for assessment of diastolic function.
However, echocardiographic techniques have limitations
which are not present in strain and strain rate
measurement using MRI. We previously developed a
full-cycle cine DENSE sequence that can accurately
compute systolic and diastolic strains and strain rates.
In the present study we compared full-cycle cine DENSE
results between hypertensive patients and healthy
volunteers. The patients showed significantly reduced
peak early diastolic strain rate and increased peak
atrial systolic strain rate compared to volunteers,
illustrating full-cycle DENSEs ability to assess
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