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Abstract #0874

Diastolic Dysfunction is Closely Associated with Myocardial Steatosis in Women at Risk for Heart Failure with Preserved Ejection Fraction

Lidia S. Szczepaniak 1 , Janet Wei 1 , Michael D. Nelson 1 , Laura G. Smith 1 , Edward W. Szczepaniak 1 , Louise Thomson 1 , Daniel Berman 1 , Debiao Li 1 , and C. Noel Bairey Merz 1

1 Cedars-Sinai Medical Center, Los Angeles, California, United States

Impaired left ventricular (LV) filling is an important manifestation of heart failure with preserved LV ejection fraction (HFpEF), and is regarded as a primary contributor to morbidity and mortality in this population. Despite our general understanding, however, the exact mechanism for diastolic dysfunction remains unclear. Myocardial fat accumulation is associated with diastolic dysfunction in other disease states and thus may play an important role in the pathogenesis of HFpEF. We directly address this hypothesis by evaluating myocardial triglyceride content and diastolic function in a patient population at increased risk for HFpEF.

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