Abstract #0897
Abnormal Iron Levels in the Brain of Pediatric Sickle Cell Disease Patients: a Study using Quantitative Susceptibility Mapping (QSM)
Deqiang Qiu 1 , R Clark Brown 2,3 , Binjian Sun 4 , Susan Palasis 4 , Thomas G Burns 5 , and Richard A Jones 1,4
1
Radiology, Emory University, Atlanta, GA,
United States,
2
Haematology,
Children's Healthcare of Atlanta, Atlanta, GA, United
States,
3
Haematology,
Emory University, Atlanta, GA, United States,
4
Radiology,
Children's Healthcare of Atlanta, Atlanta, GA, United
States,
5
Neuropsychology,
Children's Healthcare of Atlanta, Atlanta, GA, United
States
Pediatric sickle cell disease patients with high
cerebral blood flow receiving chronic blood transfusion
to reduce the risk of stroke. Quantitative
susceptibility mapping was used to study the brain iron
levels in these patients compared to a group of healthy
control subjects. Significant higher susceptibility
values were found in the patients in multiple brain
regions including the choroid plexus, red nucleus and
dentate nucleus. QSM is a sensitive tool for monitoring
brain iron level and allows customized treatment
strategy for patients with altered iron level.
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