Abstract #0896
Quantitative susceptibility mapping of Huntingtons disease at 7 Tesla
Clare B Poynton 1 , Janine M Lupo 1 , Christopher P Hess 1 , and Sarah J Nelson 1,2
1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco, CA,
United States,
2
Department
of Bioengineering and Therapeutic Sciences, University
of California, San Francisco, CA, United States
Quantifying iron deposition in Huntingtons disease and
other neurodegenerative disorders may provide insight
into disease pathogenesis, aid in patient diagnosis or
evaluating response to treatment. Iron accumulation
changes the tissue magnetic susceptibility, which can be
quantified from the MR signal phase using quantitative
susceptibility mapping (QSM). In this study, we apply
the QSIP algorithm to quantify magnetic susceptibility
in premotor Huntingtons patients imaged at 7 Tesla.
Results show statistically significant increases in QSM
estimates in the caudate, putamen and globus pallidus
relative to controls, which is consistent with
hypothesized disease-related iron deposition in these
regions.
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