Abstract #0895
Magnetic Susceptibility Contrast Variations in Multiple Sclerosis (MS) Lesions Observed at 7T
Xu Li 1,2 , Hongjun Liu 1,3 , Daniel M Harrison 4 , Craig K Jones 1,2 , Jiwon Oh 4 , Peter A Calabresi 4 , and Peter C.M. van Zijl 1,2
1
F.M. Kirby Research Center for Functional
Brain Imaging, Kennedy Krieger Institute, Baltimore, MD,
United States,
2
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
3
Radiology,
Guangdong General Hospital, Guangzhou, Guangdong, China,
4
Neurology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States
White matter magnetic susceptibility contrasts in MS
were investigated using gradient echo magnitude, R2*,
frequency, and quantitative susceptibility mapping (QSM).
For QSM, both hyperintense (increased susceptibility)
and isointense lesions were observed. A larger
proportion (88.3%) of periventricular lesions were
hyperintense, while a larger proportion (74.6%) of
subcortical lesions were isointense. Increased lesion
susceptibility may indicate either iron deposition or
demyelination, while decreased R2* suggests myelin loss
or low iron concentration. All R2* lesions appeared
darker than normal white matter and all susceptibility
lesions brighter or isointense, suggesting myelin loss
as the dominant pathologic mechanism accounting for the
observed findings.
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