Abstract #0894
Iron accumulation is a rare feature in multiple sclerosis lesions
Vanessa Wiggermann 1,2 , Lisa E. Lee 3 , Enedino Hernndez Torres 1,4 , David K.B. Li 1,4 , Alex L. MacKay 2,4 , Irene M. Vavasour 1,4 , Anthony Traboulsee 4,5 , and Alexander Rauscher 1,4
1
Radiology, University of British Columbia,
Vancouver, BC, Canada,
2
Physics
and Astronomy, University of British Columbia,
Vancouver, BC, Canada,
3
Science, University of
British Columbia, Vancouver, BC, Canada,
4
UBC
MRI Research Centre, Vancouver, BC, Canada,
5
Neurology,
University of British Columbia, Vancouver, BC, Canada
The contrast observed in MR frequency shift imaging in
multiple sclerosis (MS) lesions has been attributed to
iron. However, histopathology studies indicated that
iron is a rather rare feature and mainly found in the
rim of some lesions. Iron would create non-local
distortions of the magnetic field outside susceptibility
inclusions. For spheres, the non-local field effect
results in a dipole (reduced frequency around the
equator of the inclusion and increased frequency in the
direction of the magnetic field). We inspected 37
enhancing and 90 non-enhancing nearly spherical lesions.
Only 4% of these lesions showed the described feature.
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