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Abstract #0893

Susceptibility and Relaxation Tensor Properties of Multiple Sclerosis Lesions at 3T

Cynthia Wisnieff 1 , Alexey Dimov 1,2 , David Pitt 3 , and Yi Wang 1,2

1 Biomedical Engineering, Cornell University, Ithaca, New York, United States, 2 Radiology, Weill Cornell Medical College, New York, New York, United States, 3 Neurology, Yale University, New Haven, Connecticut, United States

This preliminary data explores changes in the susceptibility (STI) and relaxation tensor (R2*T) properties of multiple sclerosis (MS) lesions in MRI as a result of structural changes that occur as a result of demyelinating process that occurs within these lesions. Ex vivo brain specimens were examined in an unconstrained susceptibility and relaxation tensor reconstruction to explore changes in the anisotropy, alignment and mean tensor properties were examined. This works shows significant loss of alignment within lesions while major white matter tracts retain significant alignment and anisotropy.

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