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Abstract #0914

Assessment of the response of colorectal tumours to imatinib mesylate therapy using carbogen and hypercapnia gas challenges

Miguel R. Goncalves 1 , Simon Walker-Samuel 1 , Rajiv Ramasawmy 1,2 , Sean P. Johnson 2 , R. Barbara Pedley 2 , and Mark F. Lythgoe 1

1 UCL Centre for Advanced Biomedical Imaging, Division of Medicine, London, United Kingdom, 2 UCL Cancer Institute, London, United Kingdom

We present the results of a tumour therapy study with the antiangiogenic agent imatinib mesylate, which was assessed using gradient-echo MRI alongside hyperoxia and hypercapnia challenges. Median carbogen-ΔR2*, carbogen-ΔR1 and hypercapnia-ΔGRE-SI did not change with therapy. However, significant changes in the spatial heterogeneity of carbogen-ΔR2* and hypercapnia-ΔSI were observed. These results are possibly due to the combined effect of a number of localised phenomena, given the heterogeneous nature of the tumour vasculature.

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