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Abstract #0915

Imaging biomarkers of cell death: a comparison between viscoelasticity and ADC in an orthotopic breast cancer xenograft model

Jin Li 1 , Yann Jamin 1 , Jessica K.R. Boult 1 , John C. Waterton 2 , Ralph Sinkus 3 , Michelle D. Garrett 4 , and Simon P. Robinson 1

1 Division of Radiotherapy & Imaging, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Personalised Healthcare and Biomarkers, AstraZeneca, Macclesfield, Cheshire, United Kingdom, 3 BHF Centre of Excellence, Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St Thomas' Hospital, London, United Kingdom, 4 Division of Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, United Kingdom

Comparison of MRE-derived imaging biomarkers of viscoelasticity (|G*|) and ADC in orthotopically propagated BT474 breast cancer xenografts revealed a close spatial association and quantitative correlation of reduced |G*| and elevated ADC with pathologically-confirmed cell death. A stronger and more significant correlation between |G*| and cell death supports |G*| as a potentially more sensitive biomarker of cell death than ADC.

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