Abstract #0916
MRI Evaluation of a Peptide-Coated Nanoparticle as a Potential Therapy Against Preclinical Brain Metastatic Breast Cancer
Amanda M Hamilton 1 , Sallouha Aidoudi-Ahmed 2 , Venkata R Kotamraju 2 , Shweta Sharma 2 , Paula J Foster 1 , Kazuki N Sugahara 2 , Erkki Ruoslahti 2 , and Brian K Rutt 3
1
Robarts Research Institute, London, Ontario,
Canada,
2
Sanford-Burnham
Medical Research Institute, California, United States,
3
Stanford
University, California, United States
MRI was used to evaluate the treatment efficacy of iRGD-NW,
a magnetic nanoparticle coated with a tumor-penetrating
peptide in a preclinical breast cancer brain metastasis
model. Mice received saline, iRGD-NW (tumor-homing) or
CRGDC-NW at day (td) 6 or 12 post-cell injection. Tumor
formation was evaluated by MRI at two time points after
treatment administration. Td6 iRGD-NW mice displayed
significantly lower tumor burden and signal void
retention than that of saline mice. There was no
observed treatment effect for td12 mice. Results showed
that iRGD-NW had a significant time-dependent effect on
tumor burden and suggest a potential use in metastasis
prevention.
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