Abstract #0917
Early therapy evaluation of sunitinib for gastrointestinal stromal tumors using quantitative perfusion and diffusion weighted magnetic resonance imaging: a pilot study
Hyunki Kim 1 , Desiree Morgan 1 , David Sarver 2 , Kyle Lee 1 , T. Beasley 1 , and James Posey 1
1
University of Alabama at Birmingham,
Birmingham, AL, United States,
2
University
of Arkansas for Medical Sciences, AR, United States
Quantitative DCE-MRI and DWI were successfully utilized
in GIST patients to measure the perfusion and diffusion
parameters of tumors. Significant decreases of Ktrans
and kep values were observed in GISTs after sunitinib
therapy, while tumor ADC values were significantly
increased likely reflecting favorable anti-tumor
effects. Tumor Ktrans change was significantly
correlated with tumor-volume change, and therefore it
may serve as an effective surrogate biomarker,
especially when applied at earlier time points, to
assess the therapeutic efficacy of sunitinib.
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