Evidence for Caution in DCE-MRI Assessment of Response to Antiangiogenic Therapy Using the Reference Tissue Method

DCE-MRI studies were performed on eight soft-tissue sarcoma patients to assess responses to treatment regimen of antiangiogenic agent plus conventinal chemoradiotherapy. Significant Ktrans and kep decreases were found in normal muscle regions adjacent to the tumor following initial 2 weeks of antiangiogenic therapy only. The results suggest that caution must be taken in DCE-MRI evaluation of response to antiangiogenic treatment using the reference tissue method.

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