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Abstract #0921

Variations in DCE-MRI Assessment of Breast Cancer Therapy Response: A Multicenter Data Analysis Challenge

Wei Huang 1 , Xin Li 1 , Xia Li 2 , Ming-Ching Chang 3 , Matthew J Oborski 4 , Dariya I Malyarenko 5 , Mark Muzi 6 , Guido H Jajamovich 7 , Andriy Fedorov 8 , Yiyi Chen 1 , Alina Tudorica 1 , Sandeep N Gupta 3 , Charles M Laymon 4 , Kenneth I Marro 6 , Hadrien A Dyvorne 7 , James V Miller 3 , Thomas L Chenevert 5 , Thomas E Yankeelov 2 , James M Mountz 4 , Paul E Kinahan 6 , Ron Kikinis 8 , Bachir Taouli 7 , Fiona Fennessy 8 , and Jayashree Kalpathy-Cramer 9

1 Oregon Health & Science University, Portland, Oregon, United States, 2 Vanderbilt University, Nashville, Tennessee, United States, 3 General Electric Global Research, Niskayuna, New York, United States, 4 University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 5 University of Michigan, Ann Arbor, Michigan, United States, 6 University of Washington, Seattle, Washington, United States, 7 Icahn School of Medicine at Mount Sinai, New York, New York, United States, 8 Brigham and Womens Hospital and Harvard Medical School, Boston, Massachusetts, United States, 9 Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States

Seven institutions of the NCI-sponsored Quantitative Imaging Network (QIN) participated in a DCE-MRI data analysis challenge, in which 12 pharmacokinetic models/algorithms (including Tofts model, extended Tofts model, and Shutter-Speed model) were used to analyze shared breast DCE-MRI data collected at one center before and after one cycle of neoadjuvant chemotherapy, from 10 breast cancer patients. Tumor ROI definition, AIF, and precontrast T1 were fixed for analysis of each data set across all algorithms. Considerable variations in DCE-MRI parameters were found among the algoritms with Ktrans wCV as high as 0.59. Encouragingly, Ktrans and kep values after one therapy cyles and their % changes (relative to baselin) obtained from all algorithms provided good to excellent early prediction of pathologic response.

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