Enhanced detection of cortical lesions in multiple sclerosis using magnetization transfer and double inversion recovery

Double inversion recovery (DIR) is a powerful imaging technique for detecting cortical lesions in multiple sclerosis. Yet, the number of lesions detected by DIR is significantly lower than number of lesions identified on histology. Here we propose using magnetization transfer to enhance the suppression of white matter to improve the depiction of cortical lesions. Experiments on 14 patients show that magnetization transfer DIR (MT-DIR) doubles the number of detected lesions and improves the lesion contrast by ~30%.

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