Cortical pathology is associated to proximal underlying white matte injury in multiple sclerosis: a multimodal 7T and 3T MRI study using surface based and tract based analysis.
Celine Louapre 1 , Sindhuja T Govindarajan 2 , Costanza Giann 2 , Julien Cohen-Adad 3 , Revere Philip Kinkel 4 , and Caterina Mainero 2
AA Martinos Center for Biomedical Imaging,
Charlestown, MA, United States,
Martinos Center for Biomedical Imaging, MA, United
of Biomedical Engineering Ecole Polytechnique de
Montreal, QC, Canada,
Israel Deaconess Medical Center, MA, United States
The relationship between diffuse cortical and underlying
white matter (WM) injury in multiple sclerosis (MS) is
not well understood. We used cortical thickness and
intracortical laminar T2* relaxation decay to assess
cortical injury, and to analyse its relationship with
underlying WM pathology as assessed by diffusion tensor
imaging. We found a spatial relationship between cortex
and subcortical WM pathology at the overall brain level,
and as a function of the depth from the white matter
surface within WM tracts.
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