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Abstract #0955

Cortical pathology is associated to proximal underlying white matte injury in multiple sclerosis: a multimodal 7T and 3T MRI study using surface based and tract based analysis.

Celine Louapre 1 , Sindhuja T Govindarajan 2 , Costanza Giann 2 , Julien Cohen-Adad 3 , Revere Philip Kinkel 4 , and Caterina Mainero 2

1 AA Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 AA Martinos Center for Biomedical Imaging, MA, United States, 3 Institute of Biomedical Engineering Ecole Polytechnique de Montreal, QC, Canada, 4 Beth Israel Deaconess Medical Center, MA, United States

The relationship between diffuse cortical and underlying white matter (WM) injury in multiple sclerosis (MS) is not well understood. We used cortical thickness and intracortical laminar T2* relaxation decay to assess cortical injury, and to analyse its relationship with underlying WM pathology as assessed by diffusion tensor imaging. We found a spatial relationship between cortex and subcortical WM pathology at the overall brain level, and as a function of the depth from the white matter surface within WM tracts.

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