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Abstract #0961

Tract-Based Spatial Statistics of Diffusion MRI in Paediatric Multiple Sclerosis

Kiran K Seunarine 1 , Kshitij Mankad 2 , Michael Eyre 2 , Cheryl Hemingway 2 , and Christopher A Clark 1

1 Imaging and Biophysics, UCL Institute of Child Health, London, London, United Kingdom, 2 Great Ormond Street Hospital, London, United Kingdom

Paediatric onset multiple sclerosis (POMS) is known to result in a slower accumulation of physical disability over time despite the higher relapse rate than adult-onset MS. However, the mechanisms associated with POMS remain unclear. In this study we investigate microstructural differences between POMS patients and healthy control children using tract-space spatial statistics (TBSS). Results show widespread differences throughout the TBSS skeleton in paediatric MS compared to controls for all tensor metrics. These differences are consistent with severe demyelination. In addition to this, we observe correlations between tensor metrics and several clinical scores in the POMS patient group.

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