Abstract #0961
Tract-Based Spatial Statistics of Diffusion MRI in Paediatric Multiple Sclerosis
Kiran K Seunarine 1 , Kshitij Mankad 2 , Michael Eyre 2 , Cheryl Hemingway 2 , and Christopher A Clark 1
1
Imaging and Biophysics, UCL Institute of
Child Health, London, London, United Kingdom,
2
Great
Ormond Street Hospital, London, United Kingdom
Paediatric onset multiple sclerosis (POMS) is known to
result in a slower accumulation of physical disability
over time despite the higher relapse rate than
adult-onset MS. However, the mechanisms associated with
POMS remain unclear. In this study we investigate
microstructural differences between POMS patients and
healthy control children using tract-space spatial
statistics (TBSS). Results show widespread differences
throughout the TBSS skeleton in paediatric MS compared
to controls for all tensor metrics. These differences
are consistent with severe demyelination. In addition to
this, we observe correlations between tensor metrics and
several clinical scores in the POMS patient group.
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