Abstract #0981
Simultaneous multi-slice imaging of multiple metabolites using spectral-spatial excitation for hyperpolarized 13C experiments
Angus Z. Lau 1,2 , William Dominguez-Viqueira 3 , Albert P. Chen 4 , Charles H. Cunningham 3,5 , Matthew D. Robson 1 , and Damian J. Tyler 1,2
1
Department of Cardiovascular Medicine,
University of Oxford, Oxford, United Kingdom,
2
Department
of Physiology, Anatomy, and Genetics, University of
Oxford, Oxford, United Kingdom,
3
Imaging
Research, Sunnybrook Health Sciences Centre, Toronto,
ON, Canada,
4
GE
Healthcare, Toronto, ON, Canada,
5
Department
of Medical Biophysics, University of Toronto, Toronto,
ON, Canada
DNP-dissolution MRI is a novel method for imaging in
vivo metabolism in real-time. Spectral-spatial
excitation can be used to obtain full 3D volumes rapidly
in a multi-slice mode, but for substrates with many
downstream metabolites or multiple polarized substrates,
excitation of metabolic resonances one at a time becomes
challenging due to limited available scan time. In this
abstract, we combine simultaneous multi-slice (SMS)
acceleration with spectral-spatial excitation. We
demonstrate the method in a water/acetone phantom
(7-fold acceleration) and in retrospectively aliased 13C
cardiac images (2-fold acceleration). We anticipate the
scan time reduction will enable new applications in
hyperpolarized 13C MRI.
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