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Abstract #0982

Dynamic Ultrafast 2D Exchange Spectroscopy (EXSY) of Hyperpolarized Substrates

Christine Leon Swisher 1,2 , Peder E.Z. Larson 1,2 , Bertram L. Koelsch 1,2 , Subramaniam Sukumar 1 , Renuka Sriram 1 , Justin Delos Santos 1 , Adam B. Kerr 3 , John M. Pauly 3 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2 UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States, 3 Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, CA, United States

We present for the first time a simple ultrafast method for acquiring dynamic 2D Exchange Spectroscopy (EXSY) using MAD-STEAM. This technique reconstructs 2D EXSY spectra from 1D spectra based on phase accrual during the echo time. Utilizing single-step encoding and single-shot acquisition, it is ideal for dynamic imaging of many exchange pathways and applicable to hyperpolarized substrates. We have validated this method in simulations, hyperpolarized hydration experiments, and cell studies where forward and backward exchange of pyruvate-lactate and pyruvate-hydrate were resolved in real-time. This new approach could improve specificity to cancer metabolism via isolation of directionality of metabolic pathways.

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