Abstract #0982
Dynamic Ultrafast 2D Exchange Spectroscopy (EXSY) of Hyperpolarized Substrates
Christine Leon Swisher 1,2 , Peder E.Z. Larson 1,2 , Bertram L. Koelsch 1,2 , Subramaniam Sukumar 1 , Renuka Sriram 1 , Justin Delos Santos 1 , Adam B. Kerr 3 , John M. Pauly 3 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2
1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco, San
Francisco, CA, United States,
2
UC
Berkeley-UCSF Graduate Program in Bioengineering, San
Francisco, CA, United States,
3
Magnetic
Resonance Systems Research Laboratory, Department of
Electrical Engineering, Stanford University, Stanford,
CA, United States
We present for the first time a simple ultrafast method
for acquiring dynamic 2D Exchange Spectroscopy (EXSY)
using MAD-STEAM. This technique reconstructs 2D EXSY
spectra from 1D spectra based on phase accrual during
the echo time. Utilizing single-step encoding and
single-shot acquisition, it is ideal for dynamic imaging
of many exchange pathways and applicable to
hyperpolarized substrates. We have validated this method
in simulations, hyperpolarized hydration experiments,
and cell studies where forward and backward exchange of
pyruvate-lactate and pyruvate-hydrate were resolved in
real-time. This new approach could improve specificity
to cancer metabolism via isolation of directionality of
metabolic pathways.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
