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Abstract #0984

Quantified pH imaging with hyperpolarized 13 C-Bicarbonate

David Johannes Scholz 1 , Martin A. Janich 2 , Annette Frank 3 , Ulrich Kllisch 1 , Jan H. Ardenkjaer-Larsen 4,5 , Rolf F. Schulte 2 , Markus Schwaiger 3 , Axel Haase 1 , and Marion I. Menzel 2

1 IMETUM, Technische Universitt Mnchen, Munich, Germany, 2 GE Global Research, Munich, Germany, 3 Nuclear Medicine, Technische Universitt Mnchen, Munich, Germany, 4 Technical University of Denmark, Copenhagen, Denmark, 5 GE Healthcare, Copenhagen, Denmark

Hyperpolarized 13 C-Bicarbonate pH mapping enables the opportunity to investigate a key parameter in many biochemical processes, the pH, which is relevant for a broad range of disease characterization such like cancer, inflammatory diseases (e.g. Alzheimer disease, multiple sclerosis and osteoarthritis), hypoxia and many others. In vitro and in vivo quantification of pH, acquired spatially and time resolved helps to reveal the potential and the limits of the method. pH mapping was applied in vivo using tailor-made spectral-spatial pulse design and acquisition techniques on rats, investigating induced metabolic alkalosis in kidneys and sterile inflammation.

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