Abstract #0985
Imaging of tumor metabolism: a longitudinal study of tumor response to therapies using hyperpolarized [1- 13 C]pyruvate.
Heeseung Lim 1 , Kundan Thind 1 , Timothy Pok Chi Yeung 1,2 , Francisco M Martinez-Santiesteban 1 , Eugene Wong 2,3 , Paula J Foster 1,4 , and Timothy J Scholl 1,4
1
Medical Biophysics, Western University,
London, Ontario, Canada,
2
London
Regional Cancer Program, London Health Sciences Centre,
London, Ontario, Canada,
3
Physics
and Astronomy, Western University, London, Ontario,
Canada,
4
Robarts
Research Institute, Western University, London, Ontario,
Canada
This longitudinal study uses hyperpolarized
13
C
MRSI to image and quantify metabolic changes in brain
tumor in response to therapies. Wistar rats showed
significant changes in tumour metabolism within a day or
two after therapy measured by the ratio of lactate to
pyruvate after injection of hyperpolarized [1-
13
C]pyruvate.
This work establishes evidence for the capability of
hyperpolarized
13
C
MRSI to detect early metabolic changes in brain tumors
in response to radio- and chemotherapies and the ratio
of lactate to pyruvate as a longitudinal non-invasive
biomarker for therapeutic response.
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