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Abstract #0988

Hyperpolarized 13 C-acetate for the detection of metabolic response of the heart to a stress protocol

Ulrich Koellisch 1,2 , Concetta V. Gringeri 2,3 , Giaime Rancan 4 , Markus Durst 1,2 , Markus Schwaiger 3 , Marion I. Menzel 2 , Axel Haase 1 , and Rolf F. Schulte 2

1 IMETUM, Technical University Mnchen, Munich, Germany, 2 GE Global Research, Munich, Germany, 3 Nuclear Medicine, Technical University Mnchen, Munich, Germany, 4 Technical University Mnchen, Munich, Germany

Acetate metabolism plays an important role particularly in myocardial cells where acetate gets converted to acetyl-carnitine (ALCAR) via Acetyl-CoA. Hyperpolarized MRS using [1-13C]acetate offers the possibility to investigate its conversion to [1-13C]ALCAR, which could be a marker for changes of myocardial fatty-acid metabolism. However the low SNR of ALCAR is the bottleneck of the proposed method. Adresing this problem a stress protocol using dobutamine was combined with an optimized spectrospatial pulse sequence in order to increase the SNR of ALCAR. The results show a significant increase of the ALCAR to acetate after dobutamine administration.

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