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Abstract #0987

Measuring In Vivo Myocardial Substrate Competition Using Hyperpolarized 13C Magnetic Resonance

Jessica A.M. Bastiaansen 1 , Matthew E. Merritt 2 , and Arnaud Comment 3

1 Laboratory of Functional and Metabolic Imaging, EPFL, Lausanne, Switzerland, 2 Advanced Imaging Research Center,Department of Radiology,Molecular Biophysics,Biomedical Engineering, UTSW Medical Center, Texas, United States, 3 Institute of Physics of Biological Systems, EPFL, Lausanne, Switzerland

Cardiac dysfunction is often associated with a shift in substrate preference, while current in vivo techniques only provide direct information on substrate uptake. To study substrate competition in the rat heart in vivo, hyperpolarized [1-13C]pyruvate and [1-13C]butyrate were co-administrated as surrogates for carbohydrate and fatty acid metabolism respectively. The appearance of downstream metabolites allowed for independent monitoring of oxidation of both substrates uniquely in a single experiment. A simple metabolic intervention led to significant changes in substrate preference. Combining hyperpolarized 13C technology and co-administration of two separate imaging agents enabled the simultaneous monitoring of both fatty acid and carbohydrate oxidation in the heart in vivo.

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