Abstract #0987
Measuring In Vivo Myocardial Substrate Competition Using Hyperpolarized 13C Magnetic Resonance
Jessica A.M. Bastiaansen 1 , Matthew E. Merritt 2 , and Arnaud Comment 3
1
Laboratory of Functional and Metabolic
Imaging, EPFL, Lausanne, Switzerland,
2
Advanced
Imaging Research Center,Department of
Radiology,Molecular Biophysics,Biomedical Engineering,
UTSW Medical Center, Texas, United States,
3
Institute
of Physics of Biological Systems, EPFL, Lausanne,
Switzerland
Cardiac dysfunction is often associated with a shift in
substrate preference, while current in vivo techniques
only provide direct information on substrate uptake. To
study substrate competition in the rat heart in vivo,
hyperpolarized [1-13C]pyruvate and [1-13C]butyrate were
co-administrated as surrogates for carbohydrate and
fatty acid metabolism respectively. The appearance of
downstream metabolites allowed for independent
monitoring of oxidation of both substrates uniquely in a
single experiment. A simple metabolic intervention led
to significant changes in substrate preference.
Combining hyperpolarized 13C technology and
co-administration of two separate imaging agents enabled
the simultaneous monitoring of both fatty acid and
carbohydrate oxidation in the heart in vivo.
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