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Abstract #0990

Real-time assessment of the effect of acute and chronic hypoxia on cardiac metabolism in the control and diabetic rat: an in vivo study

Lydia Le Page 1 , Oliver Rider 2 , Victoria Noden 1 , Andrew Lewis 2 , Latt Mansor 1 , Lisa Heather 1 , and Damian Tyler 1

1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 2 Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom

Diabetes is associated with a high risk of cardiovascular disease and hypoxia is potentially an important component of this risk. Here, we investigated the in vivo , real-time metabolic response of the diabetic rat heart to acute and chronic hypoxia. Acute hypoxia reduced pyruvate dehydrogenase (PDH) flux and increased lactate production in control hearts but this did not occur in diabetic hearts. Following chronic hypoxia, neither group showed alterations in cardiac PDH flux or lactate production. We have shown an acute metabolic inflexibility in the in vivo diabetic heart, which is possibly overcome over a longer hypoxic period by physiological adaptations.

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