Abstract #1002
HP- 13 C-NMR detects the alternation of LDH kinetics and redox state induced by metabolite modulation
Lin Z. Li 1,2 , Stephen Kadlececk 1 , Hoora Shaghaghi 1 , He N. Xu 1,2 , Harrilla Profka 1 , and Rahim Rizi 1
1
Department of Radiology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Britton
Chance Laboratory of Redox Imaging, Johnson Research
Foundation, University of Pennsylvania, Philadelphia,
Pennsylvania, United States
Abnormal enzyme activities and cellular redox state have
been observed in various medical conditions including
cancer, diabetes, neurodegenerative diseases and lung
diseases. We employed hyperpolarized 13C-pyruvate NMR to
investigate non-invasively how the enzyme kinetics (rate
constants) and cellular redox state may be modulated by
the levels of metabolites. Our results indicate a strong
coupling of the lactate dehydrogenase reaction with the
cellular redox state. Hyperpolarized 13C-pyruvate can be
a metabolic indicator of redox state for the study of
normal physiology and diseases.
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