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Abstract #1003

Assessment of pancreatic islets using optical projection tomography and magnetic resonance imaging

JanakiRaman Rangarajan 1,2 , Ting Yin 3,4 , Josephine Gilbert 5 , Ashwini Atre 3,4 , Anna Eriksson 5 , Tom Dresselaers 3,4 , Frederik Maes 1 , Ulf Ahlgren 5 , and Uwe Himmelreich 3,4

1 ESAT/PSI - Medical Image Computing, KU Leuven, Leuven, Belgium, 2 iMinds-KU Leuven Future Health Department, KU Leuven, Leuven, Belgium, 3 Biomedical MRI unit, Department of Imaging and Pathology, KU Leuven, Belgium, 4 Molecular Small Animal Imaging Center (MoSAIC), KU Leuven, Belgium, 5 Ume Centre for Molecular Medicine, Umea University, Sweden

Islet graft transplantation is an promising treatment practice for diabetic treatment, but progressive islet loss is a major issue, which drives the interest to study islet location and function in vivo. MRI offers high spatial resolution for in vivo assessment of pancreatic islets (PI) labeled with iron-oxide particles, but the quantification of PIs in MR is confounded by the false positive signals. Optical projection tomography (OPT) offers multi-spectral assessment of PI labeled with fluorescent markers, but only allow ex vivo measurements. Using spatial normalization methods, we co-register the multi-modal data of MRI and OPT, which allowed co-localization of PIs. The. successful co-registration of pancreatic tissue allowed cross-validation of PIs in MR images, confirming its suitability for in vivo PI imaging. This is an essential prerequisite for future validation of in vivo MRI data using beta-cell targeting iron oxide based nanoparticles

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