A Numerical Model of Manganese Distribution in Pancreatic Tissue from meMRI measurements
Ekkehard Kstermann 1 , Anke Meyer 2 , Katharina Stolz 2 , Wolfgang Dreher 1 , and Kathrin Maedler 2
AG "in-vivo-MR", FB2, Universitt Bremen,
Bremen, Bremen, Germany,
for Biomolecular Interactions Bremen, Universitt
Bremen, Bremen, Germany
Diabetes research and therapy will benefit from
non-invasive methods of analyzing pancreatic beta-cell
mass (BCM) and activity. Manganese mediated MR imaging
is a very potent tool for non-invasive measurements of
pancreatic activity. The Mn-induced signal time course
of pancreatic tissue is analyzed with a mathematical
model consisting of three sequentially ordered
compartments: a source and two pancreatic compartments.
The pancreatic MR-signal can be modeled by (i) a small
compartment with similar signal changes as in the liver
and (ii) a larger compartment characterized by a much
slower signal change.
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