Meeting Banner
Abstract #1005

Pyruvate dehydrogenase activation normalises carbohydrate metabolism and diastolic function in the diabetic heart

Lydia Le Page 1 , Oliver Rider 2 , Andrew Lewis 2 , Lucia Giles 1 , Vicky Ball 1 , Latt Mansor 1 , Lisa Heather 1 , and Damian Tyler 1

1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 2 Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom

Diabetics have reduced systemic glucose metabolism, partly due to reduced pyruvate dehydrogenase (PDH) flux, which leads to high blood glucose levels. Dichloroacetate (DCA) stimulates PDH and this study investigated its in vivo effect on the diabetic heart and liver. Four weeks of DCA treatment in diabetic rats normalised blood glucose levels, restored cardiac PDH flux and elevated hepatic PDH flux compared to controls. Diastolic dysfunction, observed in the diabetic heart, was not present in diabetic rats treated with DCA. We conclude that PDH modulation may be a suitable treatment for the metabolic and functional abnormalities seen in the diabetic heart.

This abstract and the presentation materials are available to members only; a login is required.

Join Here