Reproducibility of Resting State Functional Connectivity Maps Derived from ASL CBF Data and Concurrent BOLD

Arterial spin labeled (ASL) perfusion fMRI offers the possibility of measuring cerebral blood flow (CBF) and assessing functional connectivity (FC) by means of evaluating the temporal correlations in the fluctuations of the CBF time series. The goal of this study was to evaluate and compare the reproducibility of FC maps derived from CBF and concurrent BOLD data. The results of this test-retest study show that FC derived from CBF data offers better reproducibility of the connectivity values, although slightly lower reproducibility of the spatial localization of the identified networks.

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