Evidence for a cerebral blood flow post-stimulus undershoot contributing to the BOLD undershoot

Since the discovery of the blood oxygenation level dependent (BOLD) signal, it has been noted that there is a post-stimulus undershoot. The source of this undershoot is often debated as it is unclear whether it is a neurologic, vascular or metabolic phenomenon. Here we provide evidence for a post-stimulus CBF undershoot by combining data from multiple experiments examining the response in the visual cortex to high contrast flickering checkerboard stimuli. These results suggest that previous publications may have missed CBF undershoots either due to lack of study power or imaging parameters not optimized for detecting the CBF signal.

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