Abstract #1018
Measuring absolute CMRO 2 using Asymmetric Spin Echo and hyperoxic calibrated BOLD
Alan J Stone 1 , Kevin Murphy 1 , Nicholas P Blockley 2 , Ashley D Harris 3,4 , and Richard G Wise 1
1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, United Kingdom,
2
FMRIB,
University of Oxford, Oxford, United Kingdom,
3
Russell
H. Morgan Department of Radiology and Radiological
Science, The Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States,
4
F.M.
Kirby Center for Functional Brain Imaging, Kennedy
Krieger Institute, Baltimore, Maryland, United States
Traditionally calibrated BOLD is used to measure the
maximum BOLD signal change (M) allowing measurement of
relative CMRO
2
changes
with task. Here an extension of the dual calibrated FMRI
methodology is presented which allows regional estimates
of absolute CMRO
2
to
be made. Asymmetric Spin Echo (ASE) is used to calculate
maximum BOLD signal change (M) through the measurement
of R
2
'. This is then used in a hyperoxic
calibrated BOLD experiment allowing the measurement of S
v
O
2
and
calculation of absolute CMRO
2
using
Ficks principle.
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