Abstract #1019
ATP signaling plays a key role in the BOLD Response
Jack A Wells 1 , Isabel N Christie^ 1 , Nephtali Marina 2 , Melina F Figueiredo 3 , Anya G Teschemacher 3 , Sergey Kasparov 3 , Alexander V Gourine* 2 , and Mark F Lythgoe* 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, London, United
Kingdom,
2
Neuroscience,
Physiology and Pharmacology, UCL, London, United
Kingdom,
3
School
of Physiology and Pharmacology, University of Bristol,
Bristol, United Kingdom
Understanding the mechanisms of neurovascular coupling
is essential to the interpretation of fMRI BOLD signals.
Astrocytes communicate via release of ATP, however its
role neurovascular coupling has not been considered. To
explore the contribution of ATP-mediated signalling in
generation of BOLD responses, we developed a lentiviral
vector that degrades ATP, effectively preventing its
action. During bilateral forepaw stimulation, a smaller
BOLD response was observed in the forepaw region
transduced to express TMPAP relative to the control
side. These novel data indicate that astroglial ATP-signalling
is important for neurovascular coupling in the intact
brain.
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