Abstract #1020
Simultaneous fPET and fMRI for Assessing Dynamic Neurovascular and Neurometabolic Changes
Hsiao-Ying Wey 1 , Marjorie Villien 1 , Joseph B Mandeville 1 , Bruce R Rosen 1 , and Jacob M Hooker 1
1
A. A. Martinos Center for Biomedical
Imaging, Massachusetts General Hospital, Harvard Medical
School, Charlestown, MA, United States
BOLD fMRI only probes neural activity indirectly and the
signal reflects a composite change of neurovascular and
neurometabolic coupling. Complete measurements of
changes in hemodynamic responses and oxidative and
non-oxidative glucose metabolisms in response to stimuli
or tasks will facilitate our interpretation of brain
function. In this study, we circumvent the temporal
limitation of FDG PET and reinvent its use to enable a
truly dynamic detection of glucose metabolism. In
addition, we validate our approaches using global
physiological challenges. Together with simultaneously
acquired BOLD/ASL data and hypercapnic calibration, a
wealth of information can be obtained in one scan.
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