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Abstract #1037

Detection of altered adipose tissue composition in breast cancer patients using MR spectroscopy

Palamadai N Venkatasubramanian 1 , George Iordanescu 1 , Matthew M Smith 1 , Jennifer L Gnerlich 2 , Katherine Yao 3 , and Alice M Wyrwicz 1

1 Radiology, NorthShore University HealthSystem, Evanston, IL, United States, 2 Surgery, The University of Chicago Medical Center, Chicago, IL, United States, 3 Surgery, NorthShore University HealthSystem, Evanston, IL, United States

Using ex vivo MR spectroscopy we found alterations in the fatty acid composition of peritumoral adipose tissue from breast cancer patients, relative to adipose tissue from a distal location within the same breast. MR-measured compositions of breast adipose tissues could predict known pathological criteria for invasive breast cancers. Our results suggest that in vivo MRS may have potential for developing a noninvasive biomarker for invasive breast cancers.

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