Detection of altered adipose tissue composition in breast cancer patients using MR spectroscopy
Palamadai N Venkatasubramanian 1 , George Iordanescu 1 , Matthew M Smith 1 , Jennifer L Gnerlich 2 , Katherine Yao 3 , and Alice M Wyrwicz 1
Radiology, NorthShore University
HealthSystem, Evanston, IL, United States,
The University of Chicago Medical Center, Chicago, IL,
NorthShore University HealthSystem, Evanston, IL, United
Using ex vivo MR spectroscopy we found alterations in
the fatty acid composition of peritumoral adipose tissue
from breast cancer patients, relative to adipose tissue
from a distal location within the same breast. MR-measured
compositions of breast adipose tissues could predict
known pathological criteria for invasive breast cancers.
Our results suggest that in vivo MRS may have potential
for developing a noninvasive biomarker for invasive
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