Abstract #1038
Lipid Deregulation in Women Carrying the BRCA Mutations: Non invasive evaluation by two-dimensional Spectroscopy
Saadallah Ramadan 1 , Jameen Arm 2 , Gorane Santamaria 3 , Judith Silcock 4 , Jessica Buck 5 , Michelle Roy 6 , Kin Men Leong 7 , Peter Lau 7 , David Clark 4 , Peter Malycha 6 , and Carolyn Mountford 6
1
School of Health Sciences, University of
Newcastle, Callaghan, NSW, Australia,
2
Hunter
New England Health, The Mater Hospital, Callaghan, NSW,
Australia,
3
Department
of Radiology, Hospital Clinic de Barcelona, Villarroel,
Spain,
4
The
Breast & Endocrine Centre, NSW, Australia,
5
School
of Health Sciences, University of Newcastle, NSW,
Australia,
6
School of Health Sciences, Centre
for MR in Health, NSW, Australia,
7
Calvary
Mater Hospital, NSW, Australia
BRCA1 and BRCA2 genes belong to the tumor suppressor
family and patients with these genes are at increased
risk of developping breast cancer. In this study, we
apply in vivo two-dimensional 2D localized correlation
spectroscopy (L-COSY) to look for a premalignant state
in the breast tissues of apparently healthy women
carrying the BRCA gene mutations and others with a
family history. We propose the hypothesis that those
with the BRCA gene mutations would have altered
chemistry reflective of a preinvasive state.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
