Abstract #1038
Lipid Deregulation in Women Carrying the BRCA Mutations: Non invasive evaluation by two-dimensional Spectroscopy
Saadallah Ramadan 1 , Jameen Arm 2 , Gorane Santamaria 3 , Judith Silcock 4 , Jessica Buck 5 , Michelle Roy 6 , Kin Men Leong 7 , Peter Lau 7 , David Clark 4 , Peter Malycha 6 , and Carolyn Mountford 6
1
School of Health Sciences, University of
Newcastle, Callaghan, NSW, Australia,
2
Hunter
New England Health, The Mater Hospital, Callaghan, NSW,
Australia,
3
Department
of Radiology, Hospital Clinic de Barcelona, Villarroel,
Spain,
4
The
Breast & Endocrine Centre, NSW, Australia,
5
School
of Health Sciences, University of Newcastle, NSW,
Australia,
6
School of Health Sciences, Centre
for MR in Health, NSW, Australia,
7
Calvary
Mater Hospital, NSW, Australia
BRCA1 and BRCA2 genes belong to the tumor suppressor
family and patients with these genes are at increased
risk of developping breast cancer. In this study, we
apply in vivo two-dimensional 2D localized correlation
spectroscopy (L-COSY) to look for a premalignant state
in the breast tissues of apparently healthy women
carrying the BRCA gene mutations and others with a
family history. We propose the hypothesis that those
with the BRCA gene mutations would have altered
chemistry reflective of a preinvasive state.
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