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Abstract #1038

Lipid Deregulation in Women Carrying the BRCA Mutations: Non invasive evaluation by two-dimensional Spectroscopy

Saadallah Ramadan 1 , Jameen Arm 2 , Gorane Santamaria 3 , Judith Silcock 4 , Jessica Buck 5 , Michelle Roy 6 , Kin Men Leong 7 , Peter Lau 7 , David Clark 4 , Peter Malycha 6 , and Carolyn Mountford 6

1 School of Health Sciences, University of Newcastle, Callaghan, NSW, Australia, 2 Hunter New England Health, The Mater Hospital, Callaghan, NSW, Australia, 3 Department of Radiology, Hospital Clinic de Barcelona, Villarroel, Spain, 4 The Breast & Endocrine Centre, NSW, Australia, 5 School of Health Sciences, University of Newcastle, NSW, Australia, 6 School of Health Sciences, Centre for MR in Health, NSW, Australia, 7 Calvary Mater Hospital, NSW, Australia

BRCA1 and BRCA2 genes belong to the tumor suppressor family and patients with these genes are at increased risk of developping breast cancer. In this study, we apply in vivo two-dimensional 2D localized correlation spectroscopy (L-COSY) to look for a premalignant state in the breast tissues of apparently healthy women carrying the BRCA gene mutations and others with a family history. We propose the hypothesis that those with the BRCA gene mutations would have altered chemistry reflective of a preinvasive state.

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