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Abstract #1071

The Effect of Varying Diffusion-Encoding Gradient Strength and Separation on Measured Apparent Diffusion Coefficient and T2 of Prostate

Shiyang Wang 1 , Yahui Peng 1,2 , Milica Medved 1 , Steffen Sammet 1 , Ambereen Yousuf 1 , Weiwei Du 1,3 , Yulei Jiang 1 , Gregory S. Karczmar 1 , and Aytekin Oto 1

1 Department of Radiology, University of Chicago, Chicago, IL, United States, 2 School of Electronic and Information Engineering, Beijing Jiaotong University, Bejing, China, 3 Department of Information Science, Kyoto Institute of Technology, Kyoto, Japan

Hybrid DWI and T2 measurements showed improved contrast enhancement in prostate cancer diagnosis. The measured apparent diffusion coefficient can be affected by restricted diffusion, depending on the diffusion gradient separation (Δ). The effect of diffusion gradient strength (g) and Δ on prostate cancer diagnosis is unknown. Current study was performed in order to test whether acquisitions with longer Δ are affected by restricted diffusion. ADC/T2s obtained with hybrid DWI sequences with fixed and non-fixed Δs were compared and no significant differences were found. Thus restricted diffusion does not affect the ADC values at the Δ values used in hybrid imaging.

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