Abstract #1072
Triexponential function analysis on diffusion-weighted MRI in diagnosing prostate cancer
Yu Ueda 1 , Satoru Takahashi 2 , Naoki Ohno 3 , Katsusuke Kyotani 1 , Nobukazu Aoyama 1 , Hideaki Kawamitsu 1 , Yoshiko Ueno 2 , Kazuhiro Kitajima 2 , Fumi Kawakami 4 , Tomoyuki Okuaki 5 , Toshiaki Miyati 3 , and Kazuro Sugimura 2
1
Division of Radiology, Kobe University
Hospital, Kobe, Hyogo, Japan,
2
Department
of Radiology, Kobe University Hospital, Kobe, Hyogo,
Japan,
3
Faculty
of Health Sciences, Institute of Medical,
Pharmaceutical, and Health Sciences, Kanazawa
University, Kanazawa, Ishikawa, Japan,
4
Department
of Diagnostic Pathology, Kobe University Hospital, Kobe,
Hyogo, Japan,
5
Philips
Healthcare Asia Pacific, Minato-ku, Tokyo, Japan
To evaluate the clinical usefulness of triexponential
function analysis of diffusion weighted MRI for the
prostate cancer in the peripheral zone (PZ), we analyzed
three diffusion coefficients (Dp, Df, Ds) and fractions
(Fp, Ff, Fs), and compared them with the extra- and
intracellular component information measured with the
histopathological specimens and pharmacokinetic
parameters calculated with DCE-MRI. Triexponential
analysis would provide more detailed information on
diffusion and perfusion of prostate cancer
noninvasively. Moreover, our findings suggested that the
reduction of ADC in PZ cancer would be due to the
decrease of Ds that reflects intracellular diffusion.
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