Abstract #1074
Quantitative DTI Tractography of prostate gland in prostate cancer patients
Alexey A Tonyushkin 1,2 , Sandeep S Hedgire 1 , Peter F Hahn 1 , Shahin Tabatabaei 1 , Mukesh G Harisinghani 1 , and Andrew JM Kiruluta 1,2
1
Radiology Dept., Massachusetts General
Hospital, Harvard Medical School, Boston, MA, United
States,
2
Physics
Dept., Harvard University, Cambridge, MA, United States
Diffusion tensor imaging (DTI) is commonly used to
perform tractography that allows visualizing neuronal
fiber map in a brain. This technique seldom been used
for other visceral organs. We applied DTI tractography
to prostate MRI and developed a quantitative approach
that is able to discriminate tumor vs. normal tissue for
diagnostic purposes. We carried out HIPPA compliant
retrospective study of N=25 men with biopsy proven
prostate cancer. The results imply differences in tract
number in tumor vs. normal gland. Since these
differences are statistically significant we can design
a novel imaging tool to determine aggressiveness of
tumor during diagnostics.
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