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Abstract #1080

Metabolic characterization of locally advanced breast cancer in response to NAC treatment

Shiva Shojaei Moghaddam 1 , Maria D. Cao 1 , Guro F. Giskedegrd 1 , Hans E. Fjsne 1 , Steinar Lundgren 1 , Per E. Lnning 2 , and Tone F. Bathen 1

1 NTNU, Trondheim, Sr-Trndelag, Norway, 2 University of Bergen, Begren, Norway

Metabolic profiling has shown promise in breast cancer characterization. High resolution magic angle spinning MR spectroscopy was performed on biopsies obtained before and after neoadjuvant chemotherapy in patients with locally advanced breast cancer. Quantitative metabolite concentrations were related to the treatment response and survival of the patients. Glycerophosphocholine, Glycine and myo-Inositol showed significant changes in response to NAC treatment among survivors, responders and non-responders. Findings from this study indicate that the MR metabolic profile in response to NAC treatment can assist the prediction of prognosis and clinical treatment response in LABC patients.

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