Abstract #1081
NMR spectroscopy identifies two subtypes with different metabolic profiles in stem-like cells from Glioblastoma multiforme
Alessandra Palma 1 , Sveva Grande 1 , Anna Maria Luciani 1 , Antonella Rosi 1 , Mauro Biffoni 2 , Lucia Ricci-Vitiani 2 , Daniele Runci 2 , Roberto Pallini 3 , Vincenza Viti 4 , and Laura Guidoni 4
1
Dipartimento di Tecnologie e Salute,
Istituto Superiore di Sanit and INFN Sanit Group,
Roma, Italy, Italy,
2
Dipartimento
di Ematologia, Oncologia e Medicina Molecolare, Istituto
Superiore di Sanit, Italy, Italy,
3
Dipartimento
di Neurochirurgia, Universit Cattolica del Sacro Cuore,
Roma, Italy, Italy,
4
INFN
Sanit Group, Roma, Italy, Italy
Recurrence of the glioblastoma after conventional
treatments is attributed to the overgrowth of stem-like
cancer cells resistant to treatments. 1H NMR spectra run
on glioblastoma derived stem-like cells grown in
neurospheres showed intense signals common in brain and
brain tumours including NAA, creatine, myoinositol,
glutamine and neutral lipids. Unsupervised cluster
analysis performed on spectral data of cells from 27
glioblastoma patients identified two different NMR-based
groups with different metabolism. A mixed neuralastrocyte
metabolic phenotype with a strong neuronal fingerprint
prevailed in one group (15 cell lines) and an astrocytic/glioma-like
metabolism was prevalent in the other cluster (12 cell
lines).
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