The effect of choline kinase-α inhibition on lipid metabolism of breast cancer cells

Phosphatidylcholine has important roles in membrane structure and cell signaling. Increased levels of choline kinase (Chk)-α and phosphocholine (PC) are consistently observed in aggressive cancers. Understanding the roles of Chk-α in cancer can result in new therapies. We previously showed that the Chk-α protein, but not PC was essential for cell survival of two triple negative breast cancer cell lines, MDA-MB-231 and SUM149, using a Chk-α inhibitor which reduces PC but not Chk-α protein. Here we have investigated lipid metabolism in these breast cancer cells and identified PtdCho as an important factor in breast cancer cell survival.

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