Meeting Banner
Abstract #1092

Evidence of intra-patient and inter-patient heterogeneity in the microvasular characteristics of colorectal cancer liver metastases

Laura Horsley 1 , Neil Thacker 2 , Ross Little 3 , Yvonne Watson 3 , Sue Cheung 3 , Geoff Parker 3 , Gordon Jayson 1 , and Alan Jackson 2

1 Institute for Cancer Studies Christie Hospital NHS Foundation Trust, University of Manchester, Manchester, United Kingdom, 2 Wolfson Molecular Imaging Centre, University of Manchester, Manchester, Greater Manchester, United Kingdom, 3 Centre for Imaging sciences & Biomedical Imaging Institute, University of Manchester, United Kingdom

This study used DCE-MRI to compare the microvascular characteristics of liver secondaries in patients with advanced colorectal cancer. We particularly wished to demonstrate whether differences could be detected between liver secondaries in the same patient or between liver secondaries in different patients, using standard DCE-MRI techniques employed for clinical trials. In order to test this hypothesis we developed a statistical method which incorporated information on the measurement reproducibility and error for median values of parameters Ktrans, ve, vp, EF and ADC. There was more variability between liver secondaries in different patients than there was between secondaries in the same patient.

This abstract and the presentation materials are available to members only; a login is required.

Join Here