Abstract #1093
Extramural Depth of Tumor Invasion at Thin-Section MR in Rectal Cancer: associating with prognostic factors and ADC value
Tong Tong 1 , Yajia Gu 2 , Weijun Peng 2 , and He Wang 3
1
Cancer Hospital, Shanghai, Shanghai, China,
2
Cancer
Hospital, Shanghai, China,
3
MR
Research China, GE Healthcare, Shanghai, China
To assess the value of maximal extramural depth (EMD) of
T3 tumor spread on MRI as a potential noninvasive
imaging biomarker of tumor aggressiveness in rectal
cancer.Tumor EMDs differ between CEA <5 ng/mL versus5
ng/mL(P=0.013), CA19-9<27U/mL versus27 U/mL(P=0.012) ,
the groups of cN0 versus cN+ cancers (P=0.049), and
between the several groups of histological
differentiation grades (P=0.033).A significant negative
correlation (r=-0.581; P=0.001) between ADC and EMD
values was found. Significant correlations were found
between EMD values and CEA,CA19-9 level, differentiation
grade and ADC value. EMD has the potential to become an
imaging biomarker of tumor aggressiveness profile.
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