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Abstract #1093

Extramural Depth of Tumor Invasion at Thin-Section MR in Rectal Cancer: associating with prognostic factors and ADC value

Tong Tong 1 , Yajia Gu 2 , Weijun Peng 2 , and He Wang 3

1 Cancer Hospital, Shanghai, Shanghai, China, 2 Cancer Hospital, Shanghai, China, 3 MR Research China, GE Healthcare, Shanghai, China

To assess the value of maximal extramural depth (EMD) of T3 tumor spread on MRI as a potential noninvasive imaging biomarker of tumor aggressiveness in rectal cancer.Tumor EMDs differ between CEA <5 ng/mL versus5 ng/mL(P=0.013), CA19-9<27U/mL versus27 U/mL(P=0.012) , the groups of cN0 versus cN+ cancers (P=0.049), and between the several groups of histological differentiation grades (P=0.033).A significant negative correlation (r=-0.581; P=0.001) between ADC and EMD values was found. Significant correlations were found between EMD values and CEA,CA19-9 level, differentiation grade and ADC value. EMD has the potential to become an imaging biomarker of tumor aggressiveness profile.

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