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Abstract #1097

Repeatability of DCE-MRI Parameters in a Paediatric Oncology Population

Neil P Jerome 1 , Keiko Miyazaki 1 , David J Collins 1 , Matthew R Orton 1 , James d'Arcy 1 , Lucas Moreno 2,3 , Andrew D J Pearson 2,3 , Lynley V Marshall 2,3 , Fernando Carcellar 2,3 , Martin O Leach 1 , Stergios Zacharoulis 2,3 , and Dow-Mu Koh 4

1 CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 Paediatric Drug Development Team, Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, Sutton, Surrey, United Kingdom, 3 Paediatric Drug Development Unit, Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom, 4 Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom

It is essential that functional imaging-derived biomarkers have acceptable repeatability in order to have confidence in measured changes. Where paediatric populations may exhibit varying physiology/metabolism to adults, there is a need to specifically assess repeatability of DCE-MRI in a paediatric population. For a paediatric cohort (median age 11, range 6 15 years) of five extra- and seven intra-cranial solid tumours, DCE was performed on two successive days, with analysis using cohort-derived AIF and extended Tofts model. Both model-derived and model-independent parameters showed acceptable repeatability (CV<20%), with native T 1 and IAUGC60 performing best (CV 6.2 % and 12.8 % respectively).

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