Meeting Banner
Abstract #1098

Comparison of Patient-Specific and Fixed Arterial Input Functions for Assessing Treatment Response at DCE-MRI

Mihaela Rata 1 , Matthew R Orton 1 , Christina Messiou 1 , Elly Castellano 1 , Helen Young 2 , Nandita de Souza 1 , David J Collins 1 , and Martin O Leach 1

1 CRUK and EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom, 2 Early Clinical Development, AstraZeneca, Macclesfield, United Kingdom

Accurate AIF measurement in DCE-MRI studies is challenging due to various confounding factors: in clinical trials looking at treatment response a fixed AIF is often used. Whilst this removes a major source of variation, if the treatment affects the AIF, such changes will be erroneously reflected in the tissue parameters. This abstract compares the repeatability and treatment effect of Ktrans obtained using three AIFs: fixed AIF; AIF from a vessel in the DCE-MRI data; AIF obtained on the same day with a DC-CT examination. A fixed AIF is most repeatable, but the DC-CT AIF has a more significant treatment effect.

This abstract and the presentation materials are available to members only; a login is required.

Join Here