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Abstract #1107

DIFFUSION WEIGHTED MRI FOR RADIOTHERAPY TREATMENT OF LOCALLY ADVANCED CERVICAL CANCER TREATMENT RESPONSE ASSESSMENT USING DIFFERENT SEGMENTATION METHODS

Sren Haack 1 , Kari Tanderup 2 , Jesper Folsted Kallehauge 3 , Jacob Christian Lindegaard 2 , Erik Morre Pedersen 4 , and Sune Nrhj Jespersen 5,6

1 Dept. of Clinical Engineering, Aarhus University Hospital, Aarhus, Denmark, 2 Dept. of Oncology, Aarhus University Hospital, Aarhus, Denmark, 3 Dept. of Medical Physics, Aarhus University Hospital, Aarhus, Denmark, 4 Dept. of Radiology, Aarhus University Hospital, Aarhus, Denmark, 5 CFIN/MindLab, Aarhus University, Aarhus, Denmark, 6 Dept. of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Diffusion weighted MRI has shown great potential in diagnostic cancer imaging and may also have value for monitoring tumor response during radiotherapy. Before DW MRI can be used for monitoring treatment response objective methods for segmentation of the hyper-intense signal of the tumor at high b-value images should be evaluated. This study evaluates three objective segmentation methods used for monitoring treatment response of twelve patients with advanced cervical cancer treated with external beam radiotherapy followed by brachytherapy. Segmented volume, resulting mean ADC and histogram analysis are compared and evaluated.

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